the chillest way to abreviate "definitely for sure" I would recommend using it, especially if you're bro.
Guy 1: I want some nattys.

Guy 2: Defs fo sho, bro.

Broseph: I got some dome from that chick the other night. It was chill.
Broski: Defs fo sho.
by So bro, you can't handle it. February 17, 2011
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1. Literally means "definitely, totally, for sure".

2. A completely redundant yet catchy phrase used to enthusiastically say "yes" without using too many extra syllables.

3. A phrase used when you strongly agree with something.
Alex: Hey Robyn, are you going to the concert this weekend? I heard it's gonna be bomb!
Robyn: I am so there! How about you, are you going?
Alex: Yeah, I wouldn't miss it! Jeff and Evan, are you guys going?
Jeff and Evan: Def Totes Fo' Sho'!
by BandCamp2009 October 3, 2009
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