Crankles: unusually skinny, bony ankles, which in comination with other observable traits, may indicate habitual use of methampetamine, also known as crank. A "crank skank", for example, would likely have crankles. Derived from the term "cankles" - its opposite.
"Check out the crankles on that ho!; bet she'll fuck me for this fuckin' phat rail!"
The area in affected female legs where the calf meets the foot in an abrupt, nontapering terminus; medical cause: adipose tissue surrounding the soleus tendon, probably congenital, worsened by weight gain and improved in appearance only by boots. From the English "calf" meaning wide portion of the lower leg, and "ankle" meaning slender joint of leg with foot.
If I didn't have cankles, I might be able to wear those Prada loafers with my capri pants.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).