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it refers to ones butt hole, also known as asshole or anal entrance.
John: Where's the pipe?

Andrew: In my Buh Ho.
Buh Ho by traphouse heroes February 19, 2011
Related Words
Jeffrey is a friggin Buh ho.
Buh Ho by AllenlovesDebbae February 28, 2022
Invented, developed and refined by a group of highly intellectual elite homosexual prostitutes from Houston, Texas, the word "buh-hoe" can be used to describe, define or express any noun, verb, or adjective; and any idea, emotion, surname. It is often used also to fill in the proverbial blank when the user forgets an essential part of an idea he / she is communicating.
"Death of a Buh-Hoe," by E.B. White
I'm gonna go drink some buh-hoe.
buh-hoe by eBay Buh-Hoe November 2, 2004

Holy Buh 

Exclaimation; a traditional exclamation of excitement or surprise, used originally by Buddhist monks who had traveled nearby the Alexis to teach.
Holy Buh! Look at the size of that harpoon!
Holy Buh by Doc Dauber February 2, 2004
the act of saying butthole very fast to the point where it is 1 word
Glenn put his arms on the table and screamed BUHHO
buhho by the horned elephant April 8, 2012
The opening in which shit exits the body, and/or dick enters.
Alex G. sure was knockin up Ashley A.'s buhhole last night, and the night before, and the night before...
buhhole by Jimberley Kim April 30, 2005