A feeling of intense anxiety and/or psychological distress. Literally "letter pain". Named after the feeling anyone residing in Germany gets after seeing they have letters in their postbox. To be used literally or metaphorically.
LITERAL:

"Hey, wanna go for a späti beer?"
"Can't dude, just saw a letter from the finanzamt and the briefschmerz is REAL"

METAPHORICAL

"OMG my boss called me in for a meeting and I thought I was in trouble and I had a full on briefschmerz episode"
by Berlin Auslander Memes June 7, 2020
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