A bizzle is a word often used by middle class european american youths who intend to "ghetto up" there vocabulary when in fact it has no meaning at all and therefore exposes there true nature. (80's exuivlant- "Yo, loose dazero and get wit da hero. Word t' yur mudda.")
Johny- "Yo, What up dog?"
Jimmy- "Not much, you down wit a bizzle my nizzle?
stands for being high as a bird or "h as a b/hasab", Its when u been tokin on that jay jay (marijuana) and you are high as fuck and just feenin for anything.