A variation of 2cool4u. When someone acts like s/he is "too cool" for something/under a high-pressure situation, not necessarily school per se, but something deemed to be of importance, such as relationship, work, family, or even YOU.
Girl: I graduated from Y School! Are you an alum too?
Boy: I went to X School, then Y School, cuz I didn't feel like finishing my degree at X.. Then I transfered to Z School.. Can't remember anymore. Anyway, does it matter?
*Boy lights a cigarette*
*Girl whispers to friend (Hel-lo Mr. 2kool4skool!)*
Refers to a 2-panel comic or sequence where a character initially expresses overconfidence only to get defeated and/or humiliated. The term originated in the manga fandom, and while it has SFW origins the term is now mainly used within hentai and yiff communities, where it is often used in a pornographic context.
Anonymous R34 Artist: "Wow I should post more instant loss 2koma. The one with Goku and Spongebob really popped off!"