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Not only do they refer to rims, but also the size of someones arms: usually the Biceps.
22s by s1yfoxx September 15, 2010
Those hardcore chrome rims 22 inches in diamiter.
Yo, homey, did you catch them 22s on that dudes car.
22s by Mikhailo July 27, 2003
A 22-ounce bottle of booze. Often Malt Liquor and Mike's Hard. Popular on College Campuses for their relative cheapness and availiability after 8pm.
Four North Militia cuts loose with 22s, biatch, that's what's up.
22s by PT Zado January 29, 2004

22s on the lac 

a cadilac with 22's
22s on the lac by dumb @$$ October 19, 2003
it means your doin work. getting it done
talking to a friend and you explain what your doing. 22s_son. doin work
22s_son by 22s_son February 22, 2011

22s on the lac 

damn look at the 22s on that lac
22s on the lac by dumb @$$ October 19, 2003