When you have to take a dump right after eating a huge bag of cheetos. Doritos and other orange texturized flavored chips do not count. You should only use the term when the situation is cheetos, not anything else. Spelling doesnt matter as long as its used in the correct context.
After you eat a big bag of cheetos you tell your buddy that youl just be a second, you go the bathroom and realize this might take a while that was a realy big bag of cheetos. For the first time ever youve come to the conclusion you have reached your limit and take a huge dump, the result... an orange duffe.
by od man December 9, 2007
Get the orange duffemug. 
The stuff left on the bottom of your weed bags. All the stems, crystals, and leafs. Often used as a cheaper alternative to buds in baking. Though often mistaken as good, and used in joints and bowls. Known to be sold for as cheap as 30-40 dollars an ounce.
by fitzy_keegs January 13, 2017
Get the duffmug. by Bobz1992 February 7, 2014
Get the duff you inmug. 
by calumhood.com October 24, 2015
Get the duffmug. The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.
by jlthomas110880 November 25, 2020
Get the Duffmug.