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Someone who is so disgustingly ugly they make others around them violently sick. They often have multiple moles, distorted facial features and scruffy hair.
Some otis' can be gay, this is not at all good. This means the person uglier, smellier and untidier.

People who are otis' have no life, and are often rather stupid. They have the lights on, but nobody's home.

Some bald children can be otis' too, they are very ugly and unwanted. But they may grow out of this name by getting better looking. For most though, this doesn't happen and they remain ugly unwanted children and rot the streets and inhabit dwellings no other people could imagine. Otis' really are dispicable people.
DUDE 1: I have such an ugly face.
DUDE 2: No mate you don't loook over there
*points*

That is an Otis, you are truly beautiful compared to him. Love you bro, now bend over.
otis by otisbanger August 4, 2010
a gerbil that has uncontrollable twitching
usually the owner of that gerbil enjoys playing war with his/her fingers.
Dude 1- Man, stop twitching!
Dude 2- I can't help it!
Dude 1- If you were a gerbil, youd be such and Otis!
otis by twitchuncontrollably January 21, 2008
The youngest member of the Denver, Colorado independent rap duo Axe Murder Boyz formerly of Pyschopathic Records.
Otis is James Garcia, Husband to Cassandra - Father of 1.
Otis by Z*Katz February 6, 2008
When you’re slamming a girl from behind and you throw up on her back
Otis: man I was piping Cassandra last night and I threw up on her back
Bhu: wow you pulled an otis
Otis by yung swaggy May 7, 2018
Any man that is a particularly conspicuous alcoholic in comparison to other residents of his hometown. A reference to Otis Campbell who was the town drunk on the Andy Griffith Show as played by Hal Smith.
I may take an occasional drink, but I'm not Otis of Coventry.
Otis by lefty lomond September 9, 2018
A big willy and gets a lot of women

.bit of a player not going to lie. Is 100% straight but doesn’t like many people
Otis by Totis09 December 16, 2018