1) v.t. Neuroadapted.
One is "zapped" when he is depressed on account of being elated at an earlier time.
Explanation:
There is an idea in neurochemistry that the proliferation of pleasure causing neurotransmitters (i.e. dopamine) will actually decrease one's sensitivity to those neurotransmitters (because organisms tend to maintain homeostasis. There various physiological mechanisms. The presence of dopamine, for instance, probably downregulates the dopamine receptor in the post-synaptic neuron, upregulates the enzymes that break down dopamine in the synapse, and upregulates the mechanisms that re-uptake dopamine in the pre-synaptic neuron.
Supposedly, individuals suffering from bipolar disorder tend to overshoot resting levels of neurotransmitters, altrenating between manic and depressed phases.
One is "zapped" when he is depressed on account of being elated at an earlier time.
Explanation:
There is an idea in neurochemistry that the proliferation of pleasure causing neurotransmitters (i.e. dopamine) will actually decrease one's sensitivity to those neurotransmitters (because organisms tend to maintain homeostasis. There various physiological mechanisms. The presence of dopamine, for instance, probably downregulates the dopamine receptor in the post-synaptic neuron, upregulates the enzymes that break down dopamine in the synapse, and upregulates the mechanisms that re-uptake dopamine in the pre-synaptic neuron.
Supposedly, individuals suffering from bipolar disorder tend to overshoot resting levels of neurotransmitters, altrenating between manic and depressed phases.
I got zapped! I was very exited after watching my football team win, and now I am depressed for no reason.
I can't stand strip clubs. I find it too arousing, and I always get zapped the morning after.
Never imbibe alcohol if you are depressed, or you will get zapped.
I can't stand strip clubs. I find it too arousing, and I always get zapped the morning after.
Never imbibe alcohol if you are depressed, or you will get zapped.
by Brandon Beaber November 19, 2004
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Zapper
• Zapper Koh
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Get the Zappelphilipp mug.Usually a teenager,who wears baggy pants with lots of straps and zippers, often with a large T-shirt of their favorite band(s).Mistaken for a Goth all the time. Zipperkids wear lots of eyeliner, and are usually rebellious. Found in arcades, or stores like Hot topic.
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Some examples of zippered nipples or laced nipple syndrome are:
Queen Latifah
Oprah Winfrey
Rosie O'donell
the fat guy on the street
Queen Latifah
Oprah Winfrey
Rosie O'donell
the fat guy on the street
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