Sister

God's worst screwup, made to teach brothers how unattractive and morally wrong the opposite sex really is.

My sister just PMSed all over me, in every way possible.

by Mac11 October 5, 2004

Sister

Your sibling that usually gets you in trouble, and tattletales 24/7/365.

Ugh, my sister keeps getting me in trouble.

by Santa Nugg December 3, 2018

Sister

Used in Texas or other southern states as a synonym for wife

"this is my wife/sister"

by GayFlute January 19, 2017

Sister

A word commonly used by the no longer relevant James Charles after he was exposed by Tati. You would say it before somebody's name, to say they are your friend.

"Omg hi sisterEmmalyn!"
"James Charles is cancelled now don't use the word and sister."

by Heeyyygirl May 15, 2019

Sister

A Person; Generally Female

You are my sister.

by leftfootrightfoot April 2, 2016

Sister

A nick name that was created for the beauty guru James Charles who in every videos beggining says "Hi Sisters! James Charles here and welcome back to my Youtube channel"

"Sister snached"

by SisterEmma December 4, 2018

Sister

1. Fans of James Charles
2. A word you can just put before any “s” word and get away with it

1. Omg you watch James, you’re a sister
2. I just sister snapped right there

by Mitochondriapowerhouseofdacell November 28, 2018