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Jane, you ignorant slut! 

Originally an ad hominem attack against Jane Curtin by Dan Akroyd on Saturday Night Live during Weekend Update. At that time, it featured a "Point/Counterpoint" in which Jane made one point, and Dan would prefix his counterpoint with this phrase.

More recently, it has become sort of a ha ha only serious opener to such a counterpoint on Usenet, typically used amidst flamewars.
Jane, you ignorant slut! You know this needs no example!

Beyond Ignorant

What do you call beyond ignorant? Patrick Boyvin
he's so beyond ignorant he's Patrick Boyvin.
Beyond Ignorant by DPoirier April 20, 2020

lil Ignorant

An ignorant young kid with an IQ of a rock that does whatever he wants and has fun doing it. He inspires his fan base to have fun and do whatever the heck they want to do. Also has been gaining a lot of clout this month and building his fan base. He has an insanely unique way of eating cereal which is pouring the milk before the cereal. He is the type of guy to leave the fridge open all night. He is the type of guy to think nickels are worth more than dimes because they are bigger. He is the type of person to cancel a doctors appointment because he’s sick.
Guy 1: lil ignorant just posted a new video on instagram people say it will make your grandma jump out of her Wheelchair.
Guy 2: haha yooo that was a funny video he really is ignorant
lil Ignorant by Jajck September 4, 2019

never ignorant getting goals accomplished

Tyrone: You know what nigga stands for, right?
CJ: Naw.
Tyrone: Never ignorant getting goals accomplished, my nigga.

Politically Ignorant 

Someone who doesn't give even the slightest shit about politics, and instead enjoys the sight of political activists acting like rabid cavemen about it.
Person 1: DID YOU SEE THAT FUCKING (Party) PROPAGANDA IN THAT ONE THING
Person 2: FUCK YOU YOU FUCKING RACIST PIG, YOU'RE WHAT'S HARMING OUR COUNTRY'S FUTURE
Person 3: WHEN (Presidential candidate) IS ELECTED, I CAN'T WAIT TO SEE YOU DISGUSTING PSEUDO NAZIS BURN IN HELL

Politically Ignorant Person: yall are fucking idiots lmao

Jane, you ignorant slut! 

An old Saturday Night Live parody of ad hominem attacks made by pundits.
"Jane, you ignorant slut!" is best rebutted with "Dan, you pompous ass!"