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smack my bitch up 

bitch being slang for the main vain running down your arm in which heroin is usually injected.
smack is slang for the drug heroin.
put them together and you get smack my bitch up, in other words to inject heroin into your main vein in your arm.

also widely known from the famous song smack my bitch up by the prodigy.
hey man, im off to smack my bitch up whilst listening to smack by bitch up
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Heroin.

Also known as Dragon, Dope, Heron, Herone, Hero, Hera, H, Big H, White, China White, White Nurse, White Lady, White Horse, White Girl, White Boy, White Stuff, Boy, He, Black, Black Tar, Black Pearl, Black Stuff, Black Eagle, Brown, Brown Crystal, Brown Sugar, Brown Tape, Brown Rhine, Chiba, Chiva, Chieva, Mexican Brown, Mexican Mud, Mexican Horse, Junk, Tar, Snow, Snowball, Scag, Scat, Sack, Skunk, Number 3, Number 4, Number 8, Bombita, Brea, Blanco, Bonita, Caballo, Calbo, Carga, Carne, Chapopote, Chatarra, Chicle, Cocofan, Gato, Heroina, La Buena, La Chiva, Polvo, Tecata, Tigre, Tigre Blanco, Tigre del Norte, Vidrio and Zoquete.
Snuffaluffagus: "I'm sick, Bird. I need some smack, Bird."

- Dave Chappelle
Smack by ROCKintheCDA November 7, 2010
Related Words
Poeple with the name seckin have got a very large dick, and are also very handsome.
"Seckin" is awesome
seckin by Zakhoff February 24, 2017

Manhattan Back Smack 

The Manhattan Back Smack is when your conducting anal sex with a gagged hog tied lady while under the effect of at LEAST 10 Viagra pills, you then smack her in the back of the head with your penis until she becomes disoriented OR passes out.

You finally finish the job by unloading a sea of hot sticky man milk on to her face...Then run like hell
Jerome: Bro! Where did you disappear last night?
You: Hey you know that hot piece of ass from last Friday?
Jerome: yeah what about her?
You: Well guess who gave that bitch the Manhattan Back Smack!

hump-smack

A dance in which you select a target, then dry hump them while smacking them violently with whatever appendage seems appropriate, at whatever degree you wish. A violent, and completely platonic dance.
Michelle is so bomb, I hump-smacked her last night.

Sam is a hump-smack CHAMP.

Megan? Shit dawg, Megan is like, the humpity-humpiest hump-smack dance devil aliveee.

flop smack

when you take off your flip flop and smack somebody in the face with it
shelby: daniel is soooo annoying.

ritchie: then just take off your shoe and flop smack him :D

bi-directional smack 

The process of talking smack back and forth. E.g.- between colleagues.

Usually referenced when someone is willing to talk smack, but unable to take it...
Dustin does not adhere to the principle of bi-directional smack. He talks smack, but cannot take it. Therefor he is a hypocritical clown.
bi-directional smack by Luc February 16, 2005