1 definition by x-meow-meow-x

bitch being slang for the main vain running down your arm in which heroin is usually injected.
smack is slang for the drug heroin.
put them together and you get smack my bitch up, in other words to inject heroin into your main vein in your arm.

also widely known from the famous song smack my bitch up by the prodigy.
hey man, im off to smack my bitch up whilst listening to smack by bitch up
by x-meow-meow-x April 2, 2008
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