The sissy hiss: that annoying, snake-like hissing sound some queens make when they speak. To other gay men it is slightly less appealing than an unwashed, yeast infected, menstruating pussy. The sissy hiss has been known to make grown men point and laugh (often to be followed by a significant gay bashing event).
Kevin is such a flamer, every time he speaks everyone is afraid a snake is attacking.
Kevin is such a flamer, the catholic church uses him to teach its priests how to do the sissy hiss.
What the other two definitions said. However this term can also be used as an insult, either generally or specifically towards someone who evokes such qualities. Use at your own risk.
Person 1: I heard Tyler couldn't evenhandle being yelled at by his boss and left his office with tears in his eyes
Person 2: Dang what a sissy slut
she dress like a dude, walk like a dude, act like a dude, and wear tighty whitties.but whines like a bitch.....
or
a good friend you trust and joke with but is whinny
Aimee stop looking at the shot glass and drink it or are you a sissy bitch.