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The Big O 

Not to be confused wih the suggestive word "Big O", this is a show where Roger Smith does random shit accompanied by a beautiful android. However every character is probably aware of the fourth wall and try too hard not to break it.
John: Did you see The Big O?
Fanny: It's only a decade-old anime.
John: But it's one of the mindfucking show I've ever seen.
The Big O by Leviaiz December 30, 2021
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The Big "O" 

"The Big O" with a woman has been elusive for Pete for many years.

The Big "O" 

Roy Orbison - One of rock music's truly legendary figures.
Ooby Dooby: "you wiggle and you shake like a big rattlesnake."
The Big "O" by Triffid June 24, 2005

The Big C.O.

The Big Cookie Overrun. A fat computer nerd.
If I gained 300 pounds and learned fortran I would be The Big C.O.
The Big C.O. by John French July 8, 2004

the big four'o 

I would think that's a phrase used when someone turns forty (40) years old
Congratulations with the big four'O , He /she celebrated the big four'O

THE BIG N.O.B 

THE BIG N.O.B Is a place in San Jose that is ran by three jocking kids that went to MMS a school near THE BIG N.O.B
THE BIG N.O.B was run by those old geezers Johann, Sami, and Aashish.

The Big Oof 

George Washington took the big oof on December 14, 1799
The Big Oof by PopeGod March 14, 2018