ISS 

Itchy Scrot Syndrome to have extremely itchy balls

person 1-What ya doing?
person2-Itching my balls
person1-Argh of course ISS

ISS by twatnose September 6, 2010

ISS 

It Still Sucks. A short way way of telling someone that they fail, again.

Person A: I re-recorded the vocals for this song.

Person B: ISS.

ISS by Shot Shiffith November 19, 2009

ISS 

In School Suspension, also known as OCS, On Campus Suspension. A beggining for punks or delinquents, the first stop before alternative school and eventually jail.

"Shit, man, I got another four days of ISS."

ISS by Styk Stoker April 25, 2004

ISS 

"I'm so sure!" said like a Valley Girl. (see also the movie Clueless)

He told you that you looked fat? ISS

ISS by GoodUncle April 3, 2013

iss 

iss is slang for in school suspension.

Brandon: “Hey want to eat with us during lunch?”
Cameron: “Sorry I can’t I have an iss.”

iss by DeeplyDefined May 20, 2018

ISS 

Itchy Scrot Syndrome
A non-contagious condition wich has seemed to spread throughout the northe east of england and is rapidly spreading across the world. Thought to be caused my shaving of the region or just over "use".

George: Hey man
Ben: Hey
George: Hows it going
Ben : Ahh I think I have ISS
George: Unlucky man, put some ice cream on it
Ben : Good Idea bro, Peace

ISS by Jelly Man April 20, 2008

iss 

to kiss with no affection towards the person

Me and Drew L. just had an awesome iss!

iss by lolo mill November 5, 2009