A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.
Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.
by NinjaSlayer_936 January 2, 2021
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1) Having messed up so bad that one has done the exact opposite thing one was trying to do
2) Having accidentally lost progress instead of gained
3) Trying to use the down escalator to go up
“The calming medicine has only made the ape more angry!” hollered the scientist. “We’ve gone up the down stairs!”

The men walked out of the maze entrance, frustrated that all the paths they took had only led them up the down stairs, as it were.

Alice wasn’t very bright at times, seeing as there was many an occasion where she was going up the down stairs at the mall.
by Shocken 2 July 30, 2022
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What the cantankerous Homer Bedloe gets stuck with doing every time he misses the Hooterville Cannonball and is therefore forced to take a manually-pumped hand-car along the tracks that run from Hooterville to Pixley.
The ultimate "puffed-up dandy-dude getting cut down to size for once" recurring gag-scene from "Petticoat Junction" is when Mr. Bedloe --- while embarked on yet another failed mission to scrap the Hooterville Cannonball --- is forced to perform his classic "Up, down! Up, down! Up, down!" routine with the handcar-lever as he solo-races a clunky hand-car from Hooterville to Pixley after he's either missed the train or is otherwise somehow prevented from "riding in style".
by QuacksO March 3, 2019
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what it sounds like they're saying in uptown funk
bad singer 1: up down f**k it up
BS 2: no it's (insert off key version of song here)
by yardardar April 5, 2021
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When receiving a head job, the giver strokes the penis in an up and down motion whilst turning their hand 180 degrees at the same time
How’d ya go last night mate? Bro, best up down 180 I’ve ever had
by Cheap_steaks November 12, 2017
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