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4 AM Syndrome 

A phenomenon which leads one's English (or whatever language one speaks) to either become less controlled or logical than usual or archaic and verbose; it also causes one to say things one wouldn't ordinarily say. Often quite embarrassing, this syndrome is most evident in those who chat or speak with friends or relatives in the wee hours of the morning.
Deb: I'm sorry about last night!! It was late, and I don't know what I was saying!
Pedro: No worries--I'm sure it was just the 4 AM Syndrome.
4 AM Syndrome by BostoniensisXX September 6, 2013
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Stale Scale Syndrome 

when a musician focuses so much on perfecting every little aspect of a scale that he begins to sound robotic and all the feeling in his/her playing becomes extinct.
person1 "wow, Michael Angelo Batio is such an amazing guitar player!"

person2 "too bad he developed a severe case of stale scale syndrome, poor guy..."
Stale Scale Syndrome by dannyhang December 21, 2013

Pac-Man Syndrome

When you eat everything in a steady rhythmic chomping motion, especially if that food is pelletized or available in small, bite sized amounts, such as combos.
"After I got high, I got Pac-Man Syndrome and ate a whole thing of candy beans."

"Your father has Pac-Man Syndrome. The prognosis isn't good. I'm afraid he only has a few months at best."
Pac-Man Syndrome by Keith Robicheux December 30, 2013

Red wedding Syndrome 

The feeling that in every book/tv show you are exposed to anytime anything slightly dramatic starts to happen, every character you like in that scene will die. Most noted after a viewer watches "Game of Thrones" red wedding scene for the first time.
"I feel bad for the poor guy, he's got red wedding syndrome and freaks out even watching Disney movies, wondering who dies next."

Sleepy Kitty Syndrome 

A person who develops Sleepy Kitty Syndrome are typically at home when the symptoms first develop. This syndrome peaks in the daytime and obviously only affects cat owners (both men and women are susceptible).

Most commonly, this syndrome begins after the man or woman show signs of procrastination and decide to sit on his or her couch to watch television, rather than do what they needed to that day. The person's pet cat will then take this opportunity to sit upon his or her lap to commence the first stages of Sleepy Kitty Syndrome.

First, the cat will become very warm and cuddly.
Second, the cat will then proceed to take a nap on the owner's lap. This is when the cat will begin transmitting Sleepy Kitty Syndrome upon the owner. Currently, scientists cannot explain how the cat does this, or why. The person/cat owner will then begin to feel unyielding tiredness and become unable to leave his or her couch for the remainder of the day. However, the current world record for being under Sleepy Kitty Syndrome is 5.5 days. The only way to combat Sleepy Kitty Syndrome is by owning a dog.**

**WARNING: Sleepy Doggy Syndrome has not yet been properly tested. Please use caution when napping with a dog.
"I really need to get a job, but I have Sleepy Kitty Syndrome so I think I will take a nap instead".

Purple Popsicle Syndrome 

Getting beaten so hard, circulation is cut off in ones schlong
Colin: Bad day bro.
Lucas: Why?
Colin: I got Purple Popsicle Syndrome from your mom

Suddenly Handsome Syndrome 

Expat slang. Same meaning as an LBH or Loser Back Home. A directionless male expat who leaves his home country for a developing economy country and is viewed as "handsome" and "successful" by the local women.
Ted is a total LBH with Suddenly Handsome Syndrome because he's lived in Asia for over 30 years and is on his third hot wife. Back in North America, he'd be nothing more than a pathetic, short, annoying dude who speaks Mandarin.