When you are so drunk that you are killing everyones high or buzz and therefore must be choked out with a pillow or some form of abnormal weapon.
When you are at that party and that annoying girl in your history class, who you thought was straightedge, comes up to you and pulls a Dirty Down Syndrome which then forces you to strangle her with a giant crayon.
thumbs down syndrome is a sickness were stupid people like to thumbs down anything and everything if they dont like what they see or read usually a response to internet videos or comments like on youtube that they dont like just to try and prove a point
bob damn bill im not feelin so good i think after readin that latest comment im coming down with thumbs down syndrome it makes me wanna go and lowrate everything that i disagree with maybe that will make me feel better about myself
Commonly known as TDS, is a term used when you accidentally send a text to a different person who you are having a separate conversation with that is completely irrelevant
(Bill to Amy) "I cant wait to see you again baby!"
(Amy to Bill) "I know, you made me feel so amazing..."