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Portmanteau of "Skill Issue", a phrase often used by gamers and social media users in general to point out someone's shortcomings, no matter the scale of the mistake(s) made. Modern equivalent of Epic Fail, Git Gud etc.
"Dude I can't even beat the first boss of Dark Souls, how do people speedrun this game?"

"I think you might just have a skissue, lol!"
skissue by anonymous February 24, 2025
Related Words

Shissing 

The act of peeing and pooping at the same time.
Bro don't go in there. I was shissing for like 20 minutes and it's a war zone.
Shissing by Ricegod1979 April 6, 2025

real shkits no poppity

when you agree with a statement with a little finesse
- yo this nigga dumb ashit. why he gotta dickeat on me Im innocent.
- fuck that nigga. real shkits no poppity.

Scan-doe-shiss

I can't believe you slept with your sister's husband, that was scan-doe-shiss!