Thumbs Down Syndrome 

People who will thumbs down/dislike many things, and mostly for no reason.

Guy 1: How's your channel going?
Guy 2: Not good with ratings, people with Thumbs Down Syndrome are swarming my channel...

Thumbs Down Syndrome by DarkCloudRevived May 2, 2016

Dress Down Syndrome 

The act of forgetting that it is dress down day and arriving in your regular work wear.

Joey turned up to work in his normal work clothes whilst all his colleagues had remembered to come in casual clothing, Poor Joey has some kind of Dress Down Syndrome.

Dress Down Syndrome by Sam Buca January 28, 2010

Double-Down Syndrome 

When someone has twice the effects of down syndrome, (only reach 2 feet tall, and only live to the age of 20) , and they always double down. They are very poor with money, and are not very good at gambling.

"Man we kicked that midget's ass last night in the club at Hold 'em"
"Yea I know, he musta had double-down syndrome or somthin'; he never could go a hand without double-down'. "

Double-Down Syndrome by 17link7 December 30, 2014

Class 1 Down Syndrome 

It's not a regularly used word in some cases. Generally to sum it up this type of down syndrome is way different. If you have class 1 it means that you are on the levels beyond stupid. You can suffer from eating Tide Pods, chalk, or key caps from your keyboard. On other lines you could be shoving screwdrivers up your ass or knives and twisting them.

Teacher: HEY! YOU! Get over here! No fireworks in school!
Retard: AAAAAAWWWW! *Shoves firecracker up ass and ignites it.*

Teacher: Well he did have Class 1 Down Syndrome.

Class 1 Down Syndrome by ratchetedboi12 February 26, 2017

Upside Down Syndrome 

Term used to describe someone who is excessively ugly. If the ugliness is beyond compare use Backflip Upside Down Syndrome

John - "Yo, check out that guy over there!"

Jane - "Man, he looks like he has upside down syndrome."

Jen - "Yeah! That girl looks like she has backflip upside down syndrome!"

John - "Harsh."

Upside Down Syndrome by dczech October 18, 2008

Sexually Transmitted Down Syndrome

Noun: Down Syndrome received by having sexual intercourse with a retard who appears to be suffering from Down Syndrome whether or not he actually does suffer from Down Syndrome.

Usually it's just a faggot who thinks he's hot shit.

"Lindsay" Lohan caught Sexually Transmitted Down Syndrome (STDS) from having sex with that one douche Matthew.

Sexually Transmitted Down Syndrome by Landon Smithismith June 10, 2008

thumbs down syndrome 

thumbs down syndrome is a sickness were stupid people like to thumbs down anything and everything if they dont like what they see or read usually a response to internet videos or comments like on youtube that they dont like just to try and prove a point

bob damn bill im not feelin so good i think after readin that latest comment im coming down with thumbs down syndrome it makes me wanna go and lowrate everything that i disagree with maybe that will make me feel better about myself

thumbs down syndrome by ODog N Cali M.C N T May 23, 2011