To lose control of one's behaviour, to the point of verbal and/or physical aggression.
We've had to deal with quarantine protocols for a week and all residents have had to remain in their suites with no visitors. Some of the residents that have more advanced Dementia are losing their shit. They're becoming physically aggressive. But to lose one's shit comes more easily with quarantine than one would otherwise think
That one friend who talks the most shit when playing basketball despite the fact that they don't have an ounce of skill or athleticism in their entire blood line.
v. diet that consists in dropping an enormous amount of ass matter from one's 2 hole; vastly more effective dieting strategy than any proposed by the money hungry Jenny Craig or fitness guru Jane Fonda.
Dan: Where you goin', man?
Don: To lose some weight.
specific to; when you see someone you haven't seen in a while in a location or situation you wouldn't normally see them in, you get really excited because you know it's gonna be a mad day/night
Paul (high af): When I see Adam I'm gonna lose my shit!
Adam: *rocks up*
Paul: ADAMMMMMM hoLY shIT