Tweak 

to be really into a particular activity.

dude, i've been tweakin' on Grand Theft Auto III for the past month!

Tweak by Anonymous August 19, 2003

tweak 

D&D term, meaning to improve beyond the usual possible limit, usually applying loopholes in "the system", many "Tweakers" are supposedly a rebellious movement started by fudge sunday! that´s Right! Fudge Sunday!!!

This Monk is so tweaked he has a potentially unlimited amount of attack, a *3 multiplyer, and a crit range of 12-20!!! Jeez!

tweak by Ser4phim January 9, 2004

tweak 

1. to spaz out or have a twitch
2. crack baby

dude, andy's tweakin on me

tweak by Krysti Moaner April 11, 2003

Tweak 

Someone that is on drugs and acting crazy usually some sort of amphetamine

Yoo john has been acting really tweak lately

Tweak by Surrfart October 18, 2017

Tweak 

Mrs. Charlton

Student on their phone... Mrs.Charlton takes it. She is a tweak

Tweak by Tweaked out November 15, 2018

tweak 

To irritate or injur a joint/bone.

I was running down the court and my ankle tweaked.

tweak by Idek😂 February 5, 2019

tweak 

someone who does something stupid

Kinley: I accidentally texted Hannah happy birthday today but her birthday is next weak.

Emma: wow you are such a tweak

tweak by huntsville256 May 7, 2019