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Downtown with Mr. Brown 

a term black men use to refer to jacking off.
Stephon: Man, im really nervous about my interview today

Laquintin: My negro, just got Downtown with Mr. Brown!

Stephon: (30 minutes later) Wow Laquintin! That really helped!

Laquintin: You know i always be gotten yo back boiii

downtown frown 

An extremely lippy vagina.

More specifically a girl with an extremely lippy vagina laying down on her side so that gravity pulls her labia downward, making a Frown.
I brought a beautiful woman home last night, but once i got her undressed i saw her Downtown Frown and said "No thx"
downtown frown by Apimpn October 23, 2013

North Central, Downtown Charleston 

North Central, Downtown Charleston is a neighborhood of artist, writers, and musicians adjacent to the equally hip neighborhoods of Wagener Terrace and Hampton Park. Creatives and trendsetters fill the fashionable cafe’s and pubs within the environs of Upper King, Morrison Drive, and Rutledge Ave, while an eclectic dining scene features everything from speakeasy styled restaurants, breweries and dive bars to artisan coffee houses and gastropubs. Art supply stores and galleries mix with shops selling authentic french pastries in sidewalk al fresco settings. The landscape is defined by early 20th century bungalows and vernacular architecture. Here too is the site of the famed Palace Auditorium where Elvis Presley and The Allman Brothers Band once performed. This area first settled by French Huguenots who escaped religious persecution is the terminus of the future "Low Line" greenway. The familial and ethnic diversity of this section makes it a desirable home for all walks of life. Forever singles, young marrieds, progressive middle agers and retired long time residents share this inclusive enclave. Also, Bill Murray owns several bars in the area...which is nice.
Girl: So Saturday is my bachelorette party, should we come to North Central, Downtown Charleston after the ceremony at my Mega Church?

Guy: Heres what you do....first keep your sorostitutes away from Upper King, then you and your husband settle down on Daniel Island (or Mt. Pleasant)......byeeeeeeeee.

DOWNTOWN 

When you're alone and life is making you lonely
You can always go - downtown.
When you've got worries all the noise and the hurry
Seems to help
I know - downtown.
SONG by old british rocker that lost it's appeal to a younger generation
DOWNTOWN by Petula Clark March 10, 2005

downtown 

"Downtown" is slang in NYC and elsewhere for heroin, as opposed to "uptown," which is crack or cocaine. This distinction is usually only necessary when the dealer happens to sell both heroin and crack or cocaine.
(Dealer's cell phone rings)
Dealer: Yeah, who's this?
Buyer: It's _______.
Dealer: What do you need?
Buyer: I need 2 downtown and 3 uptown.
Dealer: Go to 20th between Broadway and Fifth in 10 minutes.
downtown by barbarypirate June 21, 2009

Downtown Jayl 

A band of 3 people that sing punk rock, ballads and just random songs. They met online and have a really interesting history.
"what band are you rocking out to?"
"Downtown Jayl!"