the coolest part of any town, if your in a town and you're looking for cool people to chill with go downtown and make some friends. usually very tight groups of friends reside downtown.

between a person's legs

Where the cops take you for questioning, blowing a breathalizer, shoving broomsticks up your ass, or just basically to beat the shit out of you..

When you're alone and life is making you lonely
You can always go - downtown.
When you've got worries all the noise and the hurry
Seems to help
I know - downtown.

A place where one goes to get stabbed.

"Downtown" is slang in NYC and elsewhere for heroin, as opposed to "uptown," which is crack or cocaine. This distinction is usually only necessary when the dealer happens to sell both heroin and crack or cocaine.