A blend of "pussy" and "frustrated", meaning very angry at your girlfriend because she broke up with you.
Ex1: Dude, my girl just ditched me. I’m so freaking pusstrated.
Ex2: Breaking up right before engagement could be very pusstrating.
Ex3: Come on man! Stop being pusstrated!
When all your hard work on your project doesn't matter because someone with a vagina also worked on it.
I wrote over 100,000 lines of code in order to get a photograph of a black hole, but someone with a vagina changed the font colors, got all the credit and pussypassed me.