Duf 

An acronym for Designated Ugly Friend. Every hot girl has a DUF simply to make her look that much hotter. This strategy also works for average looking girls.

Hey Bill, here comes Mary and her DUF. I call Mary!

Duf by Ryan June 17, 2004

Duf 

Designated Ugly Friend

Britney: Oh my god, why is she your friend?
Jessica: I know shes ugly, but shes my duf.

Duf by Scarlett_the_Slayer November 7, 2018

DUF 

Designated Ugly Friend - the one obligatory fat chick in every group of hot chicks. see running interference

Damn, all those chicks are hot except for that one. Bailey's gonna take the duff home tonight.

DUF by AspiringdeitY August 5, 2003

duf 

designated ugly friend

"Dude that chicks UGLY!"

"Yes, she's the duf in the group."

duf by Stefany Nowak July 26, 2007

duf 

short for dueche fag

you shouldn't have done that you duf

duf by Jacob Smith February 5, 2004

Duf 

Duf is a ugly fat girl in your friend ship every body has one and there friend is much hotter than she is

I'm totally the duf in our friendship she so much hotter

Duf by Duf4466 June 23, 2020

DUF 

DUF is a word used by the almighty René Lund Chetronoch it's used to describe an action that leads something related to biotechnolegy or Ideahistory.

Look at this proteinsyntese, DUF, now we have proteins.
Then the Nazis came, DUF, world war 2.

DUF by SebTheSnake January 6, 2022