Dufflebag Share definition Flag The act of shitting in a tube sock, and then proceeding to mercilessly beat someone in the face with it. Greg pisses Johnny off by hitting on his sister, so Johnny dufflebagged the crap out of him. Dufflebag by Tiso November 1, 2006 0 0 Get merch Get the Dufflebag mug. Buy Now — $32.95 See more merch