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When something you had/were in care of (inanimate objects only) were misplaced without any idea where they may be.

Note: never apply to people/animals/cars/jobs...
"I lost my shoe. I can't find it."

Or, from 1999 Academy Award winning American Beauty:
Caroline Burnham "you LOST your job??!"
Lester Burnham: "I didn't LOSE it, it's not like 'whoops, where'd it go?' I QUIT!"
lost by asteroid smashington April 19, 2009
Whenever the surroundings around you are unfamiliar and you're stumbling around like an idiot:
you're either lost or intoxicated...
...or both.
Also a terrible show on terrible American television.
lost by Evil Bella November 28, 2004
Really shitty show on ABC, played out by no talent actors.
John: Come on man lets go watch Lost.
David: Dude,what the fuck is wrong with you.
lost by crayzz February 6, 2007
Oh? The atheists lost? Who did they lose to?.... or... To whom did the lose?
Hym “It was me. They lost to me. But that’s ok I beat everyone! Hurray me! Hahahahahahahaa!”
Lost by Hym Iam October 4, 2022
It means Sarah lost in every way, shape, and form.
Lost by Flavortownfieri July 30, 2016