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Rube Goldberg Syndrome 

n. The situation whereby a medical or medical/psychiatric condition causes a "domino effect" of other dangerous symptoms and conditions ensuing.

Named after the Rube Goldberg "contraption" machine, any machine that uses a chain reaction of events to achieve a final, trivial goal (in this particular case, possibly death).
After my brother had that bout with strep, it apparently got to his stomach and paralyzed it, giving him a nasty case of acid reflux, which in turn began to launch acid clear up into his throat and mouth, not only severely damaging his teeth... he's also he's worried he's going to get cancer one day from all that acid where it's not supposed to be. And to say nothing about all the dental surgeries he's gonna need... talk about a case of Rube Goldberg Syndrome!

(No really, it has happened.)
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Rube Goldberg

An unlikely and absurdly designed machine intended to perform a simple function in the most complicated and indirect way. Named in honor of Reuben Lucius Goldberg (1883-1970), an engineer with the City of San Francisco Water and Sewers Department who became a Pulitzer-Prize winning cartoonist, sculptor and author. His long-running comic strip, "Inventions", displayed many such devices of his own design.
My Grandfather built his own fuel injector with a Rube Goldberg set-up made of old plumbing parts.
Rube Goldberg by Unidyne December 29, 2003
Related Words

Rube Job 

Hillbilly: Hey Baby You gawna give me a head tonight.
Hot girl: 1 Rube Job coming up.
Rube Job by helifart223234 November 20, 2009

rube-ification 

rube- uneducated person usually from the country syn. hick, country bumpkin

ion -suffix meaning the process of

rube-ification refers to the uneducated and ignorant electorate revolutionizing American politics by among other things tolerating if not championing racism, sexism, homophobia, misogyny, fear, and hatred in the name of nationalism. A rubifier needs not fact checking, truth, science, or integrity to support whatever cause or complaint they are making.
The results of 2016 presidential election is dramatic evidence of the rube-ification of the United States.
rube-ification by Whitecroat November 22, 2016

Rube Goldberg Alcoholism 

Drunkenly setting a series of events in motion that ends in tragedy.
"How did the fire start?"
"Well, Mark was wasted and in reaching for his cell phone knocked over a glass, that fell on a power strip, that set the couch on fire"
"I see, classic Rube Goldberg Alcoholism"

Rube Machine

A general term for a female who looks like any specific animal, usually a horse or pig, and who often is an easy fuck, although nobody actually finds her attractive.
Bro 1 "dude i gotta get this nut off"

Bro 2 "dude call up that Rube Machine"

Bro 1 "idk man, she looks like a horse"
Rube Machine by tmullins181 December 13, 2010

Rube Goldberg

Unnecessarily complicated design or construction, to do something simple.
The water filled the bucket, the bucket weighed down causing a lever to move, causing a radio to turn on, causing vibrations and moving a ping pong ball down a small slope of wood, causing a domino chain to fall and to hit a switch, causing a light bulb to turn on. That is a Rube Goldberg