A derogatory term for a southerner; a redneck; white trash
"You know what you look like to me, with your good bag and your cheap shoes? You look like a rube. A well scrubbed, hustling rube with a little taste. Good nutrition's given you some length of bone, but you're not more than one generation from poor white trash, are you, Agent Starling? And that accent you've tried so desperately to shed: pure West Virginia. What is your father, dear? Is he a coal miner? Does he stink of the lamp?"
by The FanBoy Menace November 10, 2015
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Hick, redneck, 'an unsophisticated countryman' in Canadian and US slang
'hey, rube!' - Hunter Thompsons ESPN column
by Biggus Willus January 6, 2003
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(Ruub) an ambiguous word used to insult and degrade. Can be used as a prefix for words such as: rubbish, rubidium, rubard, ruby, rubben studdard, rubben sangwich, electric rubaloo, rubuttal, ruboumir, rubert, etc.

Most effectively conveyed with an Australian or Kiwi accent.
"Oi! Which one o' yew rubes slobadd all over thes beekwood!?"
by mongolwolod March 17, 2009
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Noun, gansta version of ruby. Red colored crystal. Often associated with diamonds and silver and gold.
"Sheeit, yo momma popped a cap in my ass and jacked my shorty's rube. Damn, I gots her that thang fo her birfday."
by BAMF Numero Tres December 1, 2005
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a nerd who solves rubik's cubes
That rube was really pissed when I messed up his rubik's cube 2 moves before solving it.
by The Abyss November 29, 2007
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A noob or indivdual who lacks skills most commnly in Diablo or Diablo 2., and is murdered to help higher levels gain experience. Rube is used in public chat to avoid giving away one motives, rubes can also be used to refer to rubies.
"Lets go rube hunting, meet ya in hell"
by Resiak September 1, 2006
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