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Tay-Sachs Disease 

Tay-Sachs disease is a rare genetic disorder in which an enzyme called hexosaminidase-A is missing. This enzyme is vital in breaking down harmful substances known as lypids. When these lypids build up in the brain they cause brain dammage, and cause death usually by the age of 3 to 5 years of age. Its autozomal recessive so both the wife, and the husband have to be carriers of the Tay-Sachs ghene to have a possibility of having a child affected with Tay-Sachs disease. If both partners are carriers they have a 1-4% chance of having a child affected with Tay-Sachs disease. Tay-Sachs disease is ALWAYS fatal.
When Fred was born genetic tests showed that he had Tay-Sachs disease disease. He died at the age of 3 years.
Related Words
The most funny person you'll come across. Never fails to make you laugh.
Sachimo is flawless. She has the cutest laugh.
Sachimo by Ksleezy August 23, 2011

Big Sachtj 

1) n. Someone who is very skilled in all aspects of life.

2) v. To be owned; mowed, plowed, wrecked, etc.
1) WOW! Big Sachtj just wrecked you guys in that tennis match!

2) Excuse me sir, I believe you just got big sachtj'd. Please don't talk to me anymore.
Big Sachtj by Artizz May 14, 2006
1. This is typically used when some arrogant, stuck up douche-bag in your school, group of friends, or place of employment has a very large head.



2. A genetic disease that is very common amongst the Jewish race.
-"He called me dumb, and I was right. What a dick!"
--"You should punch him in his Tay-Sachs head!"
Tay-Sachs by acv1 February 20, 2009

sacha baren cohen 

sacha baren cohen. ees nice.
An incredibly selfless human being whose good works save someone else's ass.
"Lo, you're such a sachi for picking up my shifts at work this weekend!"
sachi by Em T April 27, 2007