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1. This is typically used when some arrogant, stuck up douche-bag in your school, group of friends, or place of employment has a very large head.

2. A genetic disease that is very common amongst the Jewish race.
-"He called me dumb, and I was right. What a dick!"
--"You should punch him in his Tay-Sachs head!"
by acv1 February 20, 2009
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