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To Duffin, is to either
1)DR/Disrespect some1
2) Make an ass of urself
Guy 1: you just duffin'd Sean
Guy 2: you just made a Duffin of urself

Duffin by seaniebabi March 26, 2008

duffel-bag 

The act of two men double teaming a girl sexually with their penis's (one in the vagina and one in the mouth) while suspending her in air by holding her legs and arms up like a piece of luggage.
Charles and Sam duffel-bagged that girl from the party in the bathroom last night.
duffel-bag by togoodtobetrue123 January 11, 2011

Duffication 

When railing a girl doggy style a man places two fingers in the females asshole. Once the fingers are inserted into the asshole the male attempts to use those fingers to masturbate himself through her asshole. The name is mixture of defication and masturbation.
Man I tried to give her the duffication but when I tried to get that second finger in she got pissed.
Duffication by Duffman81221 January 7, 2014
An insult pertaining no certain meaning.
Hello pal, you're such a duffe!
Duffe by Cdoer July 11, 2010
"You're diffie!"
"There's no diffie..."
The Designated Ugly Fat Friend found in a group of girls out on the town. She may be a Cockblocker unless your group of guys has someone drunk enough to take her attention away from ruining your night.
"Hey Joe, you take care of the DUFFer so I can get to the hot one."

"Dude, why do I always have to do that?"
duffer by Cretin March 26, 2004