When one is too intoxicated from drugs or alcohol to function on a normal level and perform daily actions such as drive, work, go to school ect. Not nessisarily indicating a heavy level of intoxication.
I cant come into work today, i took a few more pills than average and im incapacitated.
When the poops are so bad that you cease to function as a normal human being and concede to the demands of your colon, staying as close as you can to the comfort of your own toilet.