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It is a conjunction of the phrase "let's go." First used on the television show King of the Hill by Dale Gribbel. Preferably used repeatedly and increasingly intense.
"Hey guys, sco to eat?"

"sco Sco SCO SCOOO!"

"Sco, dude."
sco by Dave Randall June 21, 2007
Waddup sco?
sco by pghdddddddddd June 20, 2014
An endangered species considered so pointless and useless that no effort is to be made towards conservation.
SCO is soon to be extinct.
SCO who?
SCO by TonyM October 23, 2003
One of the top rappers from the "ZOO" section of the grimiest city in the commonwealth of Virginia, Portsmouth. May also be kn own as "Kartel" around various sections of the city.

An Urban Legend created by the local women in late 2016 surrounding a serial killer that was known for making his victims "TAP OUT" and address him by his appropriately given handle "KING D**K"
GF: Bae can you buy me that new "Sco" mixtape

THE REGIME: " Sco just dropped The Gastronot, now i can make it through the rest of this year"

dude 1: "Aye bruh that new Sco s**t a banger"
dude 2: "Bruh stay snapping on s**t"
dude 1: "FAAAAACTSSSSS"
SCO by B.R.I.Q. CEO October 25, 2019
Noun.
1. Acronym for the Santa Cruz Operation.
2. A company with little or no moral codes, with horribly dishonest PR workers (Blake Stowell) and who uses the media to boost their already inflated stock price. This company seeks to charge money for Linux because it supposedly contains stolen lines of UNIX System V code, however, they have yet to prove their accusations in the form of lines of stolen code, documentation, etc.
3. A business model which is based on an RIAA-like model of "sue and alienate customers", however, involves taking large companies to court and just randomly sending out licensing requests for software which they don't hold the copyrights for.
"That company used to be so great until they went SCO on us."
SCO by Phirkel February 1, 2004