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1) To make unhappy.

2) Unhappy; angry.

3) To defeat a favored opponent.

4) A victory over a favored opponent.
1) Eric upset Alexandra by buying her mints, as she thought he was implying her breath smelled bad.

2) Catherine was still upset; she hadn't gotten over Mary's rude behavior at the party.

3) Lucas upset Dino, the nieghborhood's best tennis player, in the best-of-three-set match.

4) The White Sox scored a major upset over the over the Twins when Buehrle pitched a comple-game shutout.
Upset by Diggity Monkeez February 17, 2005
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A one-word summary of Super Bowl XLII.
After winning every single game and not losing one, it was a spectacular upset to finally lose in the championship game (especially against a team they beat in a spectacular regular-season encore).
upset by nick weiner October 24, 2008
When your boyfriend comes home late and then he tells you he couldn't phone because he wasn't allowed!!!
God damnit, why can't you tell I'm upset?!?!
upset by niknaks December 28, 2005
upset is an acronym for ultra pigheadedness starting every time
I know when I upset someone. I wonder if the fact that my time from submission date to publication date has gone up from no weeks to one week in Urban Dictionary means I have upset someone or are the editors becoming busier.
upset by Stias December 28, 2005
Except for; With the exclusion of; other than; but
Its super cool upset for the boring parts.
upset by michelle February 22, 2005

Upset Alert 

When an underdog team is on the verge of taking down the more popular team in any sport.
Upset Alert by Ale7x December 5, 2011

upset stomach 

(Honestly? No one has defined this yet?) When you feel pain or discomfort in your stomach due to overindulgence or something like that.
"Jeez, after that entire pizza I got an upset stomach to deal with!"
upset stomach by Durp dots July 5, 2016