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To get Your shit rocked by a closed fist.
Yo Son just got the shit duffed outta Him.
Duffed by Moe June 18, 2006
To get your ass kicked REALLY badly. If you got "duffed", you didn't just get punched in the face, hit the floor and kicked once or twice hard... you got hit in the face, hit the ground, then got hit in the face several more times, possibly had your head bashed into the cement, got kicked in the ears, neck, kidneys and various other soft spots on your body.
"Yung, that nigga D-Set laid up in the hospital. He smoked up that whole QP he was fronted by main man and got duffed."
Duffed by Krill Awareness April 15, 2006

Duffed It 

Referring to when you royally screw something up. Sometimes when you miss an easy shot in a sport.
Oh he duffed it!
Duffed It by Doo Doo Delpra June 28, 2011
The action of pounding a person's ass to the point their cheeks turn red without slapping them.
Yo man I duffed that bitch so hard her cotton picking grandma felt it dog.
Duffed by Mcduffing April 10, 2019
to demolish, destroy , beat down, kill, or win against an oppenent
you just got duffed!
duffed by R Sprizzle March 24, 2008
Duffed (v) - The act of getting used and or manipulated by an attractive, mentally unstable person of the opposite sex. Unfortunately this includes an abundance of flirting, profound mixed messages, and sexual enuendos that don't actually lead to SEX, merely the illusion that it will. The Duff usually ends by the Duff-er getting back together with their original girl/boyfriend, leaving the duff-ee with a killer case of blue balls/dry-gina.
Man, I thought this relationship was going to go somewhere, but really I was just getting Duffed!
Duffed by DFaFH April 9, 2006