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When really mad and you rearrange the words shut up to up-shut.
"Awww, are you PMSing?"
"up-shut!!!"

what up shut up

to be muttered directly after a sweet comeback.
you: are you really gonna wear that?
me: yeah. it's better than that frumpy-ass clown suit you got on. WHAT UP SHUT UP!
you: damn you got me good.
what up shut up by LDAWG9 February 6, 2008

SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP 

SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP
"Hey are you ok?"
" SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP SHUT UP"

Shut up and drink your moonshine 

Shut up and drink your moonshine is a retort to someone who has made a racist, redneck or bump kind of comment.
After hearing Cletus extolled the goodness of the KKK, partygoers told him "shut up and drink your moonshine!"

shut up, wesley 

Perhaps the most famous line from Cpt. Jean-Luc Picard in the STAR TREK: TNG episode "Datalore". Picard tells Wesley to shut up after he tries to warn the crew that they were actually talking to Lore, Data's evil twin. This also works when someone won't stop whining about something.
OTHER PERSON: You know, I wish you'd listen to me once in a while, because I happen to know...
YOU: Shut up, Wesley!
shut up, wesley by OhioMan May 26, 2014

Shut up Nigger 

When you don't particularly enjoy people of African/African American descent, and would like to request that they politely cease being so loud.
Standing in a Walmart checkout aisle, a single man has had enough of the women in front of him's screaming child.

Man: "SHUT UP NIGGER!"
Shut up Nigger by SlagFromTheEast February 13, 2017