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Two hole 

Used to refer to a female
Friend: I can't come, I have date night with my girlfriend.
Me: Don't dog the boys for a two hole
Two hole by johnyboyreallytaken October 25, 2017

Two hole 

Slang term for every female on the planet
Two hole by Charlieboi95 June 11, 2017

two hole punch

when someone shoots themselves in the head with two guns at the same time, one on one temple and one on the other temple. the bullets meet in the center and explode
that guy killed himself, two hole punch style.
best way to shoot yourself in the head is to do a two hole punch.

two-hole sit 

When a female sits atop the thigh of another person in a straddling fashion. Both the vagina and anus are in contact with the leg of the person being sat upon.
A: I could feel her warmth when she sat down on my knee
B: Yeah, the two-hole sit will get anyone in the mood! I had a slight hofty just watching.
two-hole sit by Craig McRae May 23, 2007

i'd throw it in the two hole 

An expression used to indicate that one finds a female reasonably attractive. Literally means that given the chance, you would like to engage in anal intercourse with her.
Britney: "Dad, I'd like you to meet my boyfriend, Kevin."
Dad: "Nice to meet you, Kevin. Now I want you to take good care of my daughter. She's a beautiful young lady and you should treat her with the respect she deserves."
Kevin: "You got that right, Pops. I'd throw it in the two hole. Can't wait to chuck my junk in that."
Dad: "Excuse me?"
Kevin: "Hey old man, you got a shitter around here? I got fuckin' plastered last night at the strip club and I've got some wicked beer shits."

the two hole 

A funny word for the rectum or anus of a human or animal.
That chic is a slut, she likes to take it up the two hole.
the two hole by Andy January 29, 2003