tsss Share definition Flag An expression of disapproval, contempt, or dissatisfaction conveyed by use of this sound. Also may be used as an expression in strenous situations. 1.)Kinga: Periods are fun to talk about. Lauren: It looks like I sat on a knife. Roger: Tsss, how can you bleed for 7 days without dying? 2.)As Roger went up for a layup, he tsss'd. tsss by K.B. May 26, 2005 Get the tsss mug.