tie one off

To drink to the point of extreme intoxication. Synonymous with tie one on.

Eric: I think I'm going to tie one off tonight.

by littlebadger June 19, 2009

tie one off

to shoot up drugs intravenously

Delina wanted to really "tie one off" so she bought a teener from her dealer.

by aniled June 4, 2009

Tie One Off

The act of having sexual intercourse.

If my date goes well, I plan to tie one off.

by Chumpbuster January 23, 2009