Used to describe a person when he/she is doing things in ways that are extremely out of the ordinary. This can have a negative or positive connotation, depending on context, such as describing a person who is mind-blowingly creative, or perhaps just out of control or not acting normal. In the positive light, "On some other shit" is often interchangeable with the slightly older phrase on another level. It also doubles (and originates) as a drug reference, describing a situation where a person is taking more intensedrugs than usual.
Leon: "Yo, Nicki Minaj's verse on Kanye's Monster joint was on some other shit!"
Charlie: "Yeah man, she killed it!"
Leon: "Yo, dawg, what was up with you last night at that party? You was mad sloppy..."
Charlie: "Yeah, man I was on some other shit... Natalie broke up with me."
Leon: "Yo did you seeee Frankie last night?! Boy was high as a kite!"
Charlie: "Psh yeah, he must've been on some other shit or somethin..."
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.