When one is in a situation that is so abhorrent that it couldn't possibly get any worse. The phrase "screwed with a capital S" just does not cut it when describing how horrible it is.
Person 1: Hey, man, you're twitching. What the hells wrong?

Person 2: Oh nothing, JUST MY LAPTOP CONTAINING MY 500 PAGE THESIS ON THE CURRENT GLOBAL ECONOMY CRASHED AND ITS DUE TOMORROW.. ya know, the usual shit

Person 1: Wow.. that sucks, dude.

Person 2: I know. Im screwed with a capital FUCK!!!
by xx<3Katie<3xx December 23, 2009
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Person 1: “Bailey are you okay?”
Person 2: “No I just let my pet fish drown, I’m screwed with a capital FUCK”
by 3gs December 17, 2021
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