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To die or be destroyed, or disappear gradually
"I shall perish" (I am going to die)
perish by A.K. Winding January 13, 2009
A basic bitch/THOT who deserves to die (perish).
I was walking through my college campus and passed by a girl drinking a Pumpkin Spice Latte, who was complaining to her friend about how her dad had gotten her a Mercedes instead of a Range Rover. Man, what a PERISH.
Perish by DevSuperJew September 4, 2019
The word that every Text To Speech Sonic The Hedgehog YouTube video uses.
This means that the person Sonic is talking to is most likely gonna die.
"It's time for you to perish!"
Perish by Zealth July 26, 2021

Perish the Thot.

An otherwise twist on the original definition for an unwelcomed thought combined with the definition of a promiscuous female.
You think I'd ever hook up with that ho? Perish the Thot.

perish the thought 

A reassuring way of stating to an insecure friend that their comment (whilst maybe a bit true) was silly and/or foolish and the last thing on your mind.
Sally: Hey Bob, I know you'd rather take Julia to the prom because you think she's prettier than me...

Bob: Jeez Sally, Julia over you?! Lol, Perish the thought!

Bob: ( @Julia 😉)
perish the thought by GMWilkie June 13, 2017