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Slang for the perscription drugs Percocet or Percodan, which is an opiate or painkiller, commonly used recreationally for its euphoric effect.
Ironically, Percocet is an opiate, which is a nervous system depressant, and the slang term perc cannot be verbally distinguished from perk, which means to make more alert or active.
I just popped a couple percs my doctor gave me for my back pain.

His dealer said percs were going for $1.50 a pill.
perc by A Clockwork Orange October 25, 2006
short for the narcotic perscription drug percoset or any one of its forms such as oxycodone or oxycontin; makes you feel warm, happy, and relaxed. highly addictive, people not only swallow the pill but take it orally crushed (for a faster reaction) or snort it.
I'm percin', dude, I'm feeling no pain.
perc by Xeokym December 30, 2004
short for "percolator" (I could be spelling that wrong). A perc is an additional chamber in a bong, and its purpose is to make the hit more smooth. Bongs can have multiple percs.
Jimmy-Jimmy just bought a rare discontinued triple-perc RooR bong over at his local headshop for $400. It fucking rips.
perc by Spaceman Spliff July 5, 2007
Perc is a Panda like human who usually causes a great ordeal of pandemonium. He comes from an Inca civilization who enjoys the delicassi of eating frogs. A Perc is a great furry friend and is bound to fall in love with a girl named Ale.

Everyone should have a Perc in their lives.
He is such a perc
Perc by Marcothecreator January 26, 2019
That guy's perc is so good!

Who percs for the Pentatonix?
perc by acappellagurl November 18, 2013