This is a Filipino joke from Facebook simply meaning "Fuck you with respect." Mostly used as sarcasm.
Girl1: You kinda look ugly in this picture.
Girl2: Oh my God, baliw ka ba? pakyuu with respect (Oh my God, are you crazy? Fuck you with respect)
Girl2: Oh my God, baliw ka ba? pakyuu with respect (Oh my God, are you crazy? Fuck you with respect)
by usuuwa October 8, 2020
Get the pakyuu with respectmug.