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A very respectful way of addressing one's older brother (in Japanese). Same as "o-nii-sama" or "aniki". Similar in meaning, but showing even more respect than "nii-san" or "nii-chan".
A younder sibling to his/her older brother: "I'll do as you say, nii-sama."
Related Words

Nico nico nii 

Serious definition: Nico Yazawa's catchphrase from the anime show Love Live! School Idol Project. Though this character seems mean and annoying at first glance, she uses this phrase often to cheer people up and show them that they don't need to feel sad, as they should always smile no matter the situation.
Nico nico nii~~ I'll nico nii your heart! I'm Yazawa Nico-Nico, and I'll put a smile in your heart! Remember, I'm Nico-Ni, and I love-Nico you!
Nico nico nii by ZAPBoy October 21, 2019

Nico nico nii 

The phrase mentioned by Nico Yazawa, a member of the idol group μ's (pronounced "muse") in the anime, "Love Live! School Idol Project". It can either sound really cute or really annoying to you. No in-betweens.
Nico: "Nico nico nii!!"

Umi: "stfu bruh"
Nico nico nii by Syahrul Danial August 30, 2020
see nee-san.

Japanese for Brother.
-san with a touch of respect.
-chan for cute
nee-san, your a fool.
nii-san by NiZ December 15, 2003

Nico Nico Nii 

Every weeb phrase when meeting another weeb
Or

Cancer to everyone except weeb.
Nico Nico nii oni-chan
Nico Nico Nii by Shajanrai March 31, 2017
If someone is a ‘nii amaa’ it means they have a big gap in the middle of their teeth. Their headshape looks like a coconut/ malteser. They are a brexit lad and get stuck in into those challenges, he 2 foots his opponents with no mercy and gets the badge in
Bob: ‘who’s your idol
Barry: ‘ my one is Nii amaa, he’s so brexit, I love it
nii amaa by Nii amaa lover December 28, 2022