Def 1: Four words choosen at random to form a phenomenon. Could be used to describe a prickly bastard that smells like a vaginal percussion and engages in sexual activites with his mother,
Def 2: Or shouted as a form of aggravation.
Origination: Mr. Ward's 3rd period (I think) Social Studies class post era a lame history video.
guy 1: "I can't believe she's dating that cactusqueef mother fucker."
guy 2: "Yea, he's a real douche bag."
A more polite way of saying "motherfucker", but not as polite as "mofo" or "maryland farmer"
Can be used interchangabily as a verb, noun, adjective or pronoun
"Motherqueefer!"
"Leave my motherqueefing shit alone!"
"Dad, he was so scared, he was squealing like a motherqueefer!"